We've paired our motor work with the characterization of signaling pathways required to define cell shape. Cells' use polarity signaling molecules to indicate the correct location and time to build their tissue specific morphology. These signaling molecules act in concert with the essential membrane-actin crosslinkers ezrin, radixin and moesin (ERMs) and the cytoskeletal organizer RhoA. Collectively, the findings from these studies indicate that separate GAPs are localized on a scale previously unappreciated (100-200nm) to locally regulate signaling pathways required for cell polarity and morphology. The Lombardo Lab is looking to understand how the cell manages to regulate these processes on such a minuscule scale.
The Lombardo Lab is growing! We're looking to add new members who are excited to join our group. See our contact page to reach out if you're interest in being a part of the Lombardo Lab's latest Science!